EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1)
نویسندگان
چکیده
منابع مشابه
Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis.
Cap dependent translation is mainly regulated at the level of the eukaryotic initiation factor 4E (eIF4E), the activity of which is controlled by phosphorylation and sequestration by its well established regulator, 4E binding protein 1 (4E-BP1). Both eIF4E and 4E-BP1 have been shown to be involved in the malignant progression of multiple human cancers, including colorectal cancer. However, the ...
متن کاملTranslational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities.
Eukaryotic translation initiation factor 4E (eIF4E) is the mRNA 5' cap binding protein, which plays an important role in the control of translation. The activity of eIF4E is regulated by a family of repressor proteins, the 4E-binding proteins (4E-BPs), whose binding to eIF4E is determined by their phosphorylation state. When hyperphosphorylated, 4E-BPs do not bind to eIF4E. Phosphorylation of t...
متن کاملEukaryotic translation initiation factor 4E binding protein 1 (4EBP-1) function is suppressed by Src and PP2A on extracellular matrix
Richard Seonghun Nho* and Mark Peterson Running title : Integrin-collagen interaction suppresses 4EBP-1 function Present address: Department of Medicine, University of Minnesota, 420 Delaware Street, SE, Minneapolis, Minnesota 55455 Address of corresponding author: Richard Seonghun Nho, Box 276, University of Minnesota, 420 Delaware Street SE., Minneapolis, Minnesota, 55455 Telephone: 612-625-0...
متن کاملTargeting the eukaryotic translation initiation factor 4E for cancer therapy.
The eukaryotic translation initiation factor 4E (eIF4E) is frequently overexpressed in human cancers in relation to disease progression and drives cellular transformation, tumorigenesis, and metastatic progression in experimental models. Enhanced eIF4E function results from eIF4E overexpression and/or activation of the ras and phosphatidylinositol 3-kinase/AKT pathways and selectively increases...
متن کاملTranslation Initiation Factor 4E Binding Protein 1,2 (4E-BP1,2) in Mematopoiesis And Stress Erythropoiesis
........................................................................................................................................................... 2 CONTENTS ........................................................................................................................................................... 3
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/44655